Dr. Renata Mangione received her Master’s degree in “Health and Cellular-Molecular Biology” from the University of Catania. She then had a 12-month continuous collaboration contract at the Institute of Biochemistry and Clinical Biochemistry at Università Cattolica del Sacro Cuore in Rome. Winner of a PhD position in “Basic Biomedical Sciences and Public Health” (“Studies of Biological Samples via Platforms- Oomics,”). She served as a PhD student at the same UCSC Institute.

In 2022, during the second year of her Ph.D., for a period of 10 months, she was a “Visiting Researcher” at the École Polytechnique Fédérale de Lausanne (EPFL), as part of the research period abroad stipulated by the Ph.D. itself, focusing her study on the biochemical alterations of agerelated degenerative muscle diseases, as an experimental study included in her Ph.D. research project. In the scientific-experimental field, she has gained experience in the following fields: – energy metabolism and mitochondrial dysfunction in head injury and concussion (in animal and human); – evaluation of the efficacy of innovative pharmacological treatments for the treatment of head injury and ALS; – research of tissue and circulating biomarkers in neurodegenerative diseases; study of biochemical and molecular mechanisms and search for biomarkers for male and female infertility; – study of metabolic alterations in tumor cells; – biomarkers research and diagnosis of specific metabolic and dating diseases (IEM); – evaluation of the efficacy of CRISPR-CAS9 as a possible gene therapy to counteract the progression of age-related muscle degenerative diseases.

During her research activity, Dr. Mangione collaborated with: – Institute of Inflammation and Aging, University of Birmingham, UK (Prof. Ann Logan and Antonio Belli); – Tikomed AB, Viken, Sweden (Dr. Lars Bruce); – Neuroscience and Ophthalmology Group, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, UK (Dr. Valentina Di Pietro); – Biotechnology and Bioengineering group, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (Prof. Johan Auwerx and Dr. Martin Wohlwend); – Section of Neurosurgery, Department of Emergency and Urgency, S. Eugenio/CTO Hospital, Rome, Italy (Prof. Stefano Signoretti); – Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy (Profs. Giuseppe Lazzarino, Angela Maria Amorini, Giovanni Li Volti). – Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy (Prof. Daniele Tibullo, Dr. Cesarina Giallongo) As of October 2023, he held the position of Adjunct Lecturer for the Disciplinary Scientific Area BIO/10- General Biochemistry, at UniCamillus – Saint Camillus International University of Health and Medical Sciences, Corso Di Laurea Magistrale in Medicina e Chirurgia, Venice campus.