Paolo Calligari is a researcher at the Department of Chemical Science and Technologies of the University of Rome “Tor Vergata”.
He graduated in Physics (Biophysics) at University of Rome “La Sapienza” in 2004 and received a PhD in Biophysical chemistry from the University of Pierre et Marie Curie – Paris VI (France) in 2008. From 2008 to 2017 he worked as post-doctoral researcher at the Chemistry Department of Ecole Normale Supérieure (Paris), International School of Advanced Studies (SISSA, Trieste), the Department of Chemical Science of the University of Padua. From 2017 to present he is affiliated to the Department of Chemical Science and Technologies of the University of Rome “Tor Vergata”.
His research activity focuses on combined theoretical and experimental methods for the characterization of dynamical and structural properties of proteins with a particular focus on three areas: theoretical models for the interpretation of experimental data; ligand-protein interactions; and the in-silico drug design.
More recently, he is applying multiple computational approaches to the characterization of the allosteric mechanism of the phosphatase SHP2, a multi-domain protein involved in different type of cancers and in rare genetic diseases.