1st LEVEL MASTER - A.Y. 2020/2021

EYE GENETICS

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1st LEVEL MASTER IN EYE GENETICS

The Master aims at offering participants a training for the genetic diagnosis of the retinal hereditary-familiar diseases which represent some of the main causes of blindness among newborns, children, and adults. The importance of an early genetic investigation is growing in these years, since “genic therapies” have been developed and introduced in the common clinical procedures, and they can stop the progression of the eye diseases genetically induced. At the same time, new diagnostic technologies have been developed: these allow to analyze quickly not only the single pathological gene but also the entire genome of the patient, if the diagnosis is uncertain. To undergo a genic therapy, the patient needs to be examined from a 360° viewpoint and that the data acquired by instrument are always in line with those of the genetic study. This calls for favoring the acquisition of deep competencies in the genetic analysis of the patient and of a strong scientific knowledge, together with continuous technological updates.

The final objective of the Master interests individuals who want to develop real professionals skills in the field of the eye genetics and who want to acquire competencies useful to draw the genetic picture of the patient, to indicate him/her the most effective and the safest current treatment.

The partner of the Master is the Macula & Genoma Foundation Onlus.

Expected Start Date: May 2021

Location:

  • Frontal lectures at UniCamillus University
  • Traineeship and practical activities at Macula & Genoma Foundation Onlus and at Santa Lucia IRCCS (in addition to all the other entities considered appropriate and necessary for the practice: firms, laboratories, etc..)

Language: Italian

ECTS: 60

Duration: 12 months for a total of 1,500 hours divided in:

  • Frontal lectures, seminars
  • Practical activities
  • Traineeship (150 hours)
  • Study and other individual activities, included the preparation of the final thesis

Attendance modality: the attendance is compulsory for at least the 75% of the total amount of the hours of the Master. The frontal lectures and seminars occupy one weekend per month. The traineeship schedule will be agreed with the host entity.

Places: a minimum of 12 students is necessary to activate the Master. Below the threshold, UniCamillus can decide unilaterally to not start the Master (fees already paid will be refunded).

The maximum number of students is 50.

Partner:

  

THE METHODOLOGY AND THE DIDACTIC PROGRAM

The Master’s didactics throughout the 12 months is organized as follows:

Module I: Elements of Molecular Biology (4 ECTS)

(Jung Hee Levialdi Ghiron, PhD)

  • Structure and ultrastructure of the cells
  • DNA structure
  • DNA duplication
  • DNA transcription
  • mRNA translation
  • control of the genic expression
  • molecular biology techniques

 

Module II: Principles of Genetics (6 ECTS)

(Prof. Emiliano Giardina/Raffaella Cascella, PhD)

  • Human genome and chromosomes
  • Mithocondrion genome
  • Mutations
  • Mendel’s law of Inheritance
  • Genomic imprinting and heterogeneity
  • Chromosome’s anomalies
  • Polymorphisms and inter-individual variability
  • Complex diseases
  • Epi-genetics

 

Module III: Analysis of the Human Genome (6 ECTS)

(Prof. Emiliano Giardina/Raffaella Cascella, PhD)

  • Basic approaches for the study of the human and mithocondrion genome
  • Targeted sequencing
  • Whole Exome Sequencing (WES)
  • Whole Genome Sequencing (WGS)
  • RNA–Seq
  • Digital PCR (dPCR)
  • Bioinformatic analyses

 

Module IV: Eye anatomy and embriology (4 ECTS)

(Prof. Benedetto Falsini)

  • Elements of eye embriology and the role of genes in the growth
  • Anatomy of the retina
  • Elements of neurophysiology
  • Analysis of the sensorial information
  • Processing of the light signal at the retinal and cortical level

 

Module V: Management of the biological samples (6 ECTS)

(Prof. Emiliano Giardina/Raffaella Cascella, PhD)

  • Genetic tests
  • Genetic consultation
  • Informed consent
  • DNA and RNA sources
  • Appropriateness of the sample and its correct conservation

 

Module VI: Morphological-functional analysis of the eye diseases (6 ECTS)

(Prof. Benedetto Falsini/Jacopo Sebastiani, BA)

  • Electrophysiology (ERG, PEV)
  • Microperimetry
  • Computerized perimetry
  • OCT Heidelberg
  • Angio-OCT
  • Retinography
  • Fluorescein angiography
  • Indocyanine angiography

 

Module VII: Genetics of the retinal dystrophies (6 ECTS)

(Prof. Michael Gorin/Prof. Andrea Cusumano)

  • Leber congenital amaurosis
  • Retinitis pigmentosa
  • Achromatopsia
  • Cone dystrophy (S-cone syndrome)
  • Stargardt
  • North Carolina Dystrophy
  • Choroideremia
  • Age-related macular degeneration
  • Customized precision medicine

 

Module VIII: New frontiers in the treatments for the hereditary retinal dystrophies (6 ECTS)

(Prof. Andrea Cusumano)

  • Optogenetics
  • Optopharmacology
  • Stem cells therapies
  • Genic therapy
  • Artificial vision (microchip)

ACADEMIC STAFF

Course Director: Prof. Andrea Cusumano, MD, PhD, Researcher at Tor Vergata University

  • APL Professor in Ophthalmology, University of Bonn
  • Adjunct Associate Professor, Cornell University, New York
  • Macula & Genoma Foundation Onlus , Rome

Lecturers:

  • Benedetto Falsini, MD, PhD: Associate Professor at Università Cattolica del Sacro Cuore – Agostino Gemelli Hospital, Rome
  • Emiliano Giardina, PhD: Associate Professor and Forensic Genetics Laboratory Director at Tor Vergata University, Rome; UILDM Genomic Medicine Laboratory Director at Fondazione Santa Lucia IRCCS, Rome
  • Raffaella Cascella, PhD: Researcher at Fondazione Santa Lucia IRCCS and at Tor Vergata University, Rome
  • Jacopo Sebastiani, BA: Consultant, Macula & Genoma Foundation Onlus, Rome Vision Clinic, Rome
  • Jung Hee Levialdi Ghiron, PhD: Consultant, Macula & Genoma Foundation Onlus, Rome Vision Clinic, Rome
  • Michael Gorin, MD, PhD: Head of the Retinal Disorders and Ophthalmic Genetics Division in the Department of Ophthalmology at the David Geffen School of Medicine – UCLA, and Jules Stein Eye Institute, Los Angeles

 

ADMISSION REQUIREMENTS AND SELECTION PROCEDURE

To be admitted to the Master, candidates must have at least one among the following typologies of Degree (already achieved or to be achieved by the deadline for the enrolment to the Master):

  • Medicine and Surgery Degree
  • Orthoptics and Ophthalmological Care
  • Biological Sciences

Candidate can apply also if in possession of:

  • A degree equivalent to the abovementioned, achieved under the previous University Didactic Organization System
  • A foreign degree that can be considered equivalent to the above mentioned as regards the duration and the contents.

The University reserves the right to allow the admission of candidates with a degree different from the previous ones.

Admission to the Master may be subject to a selection procedure on the basis of the candidates’ curricula; a ranking will then be published. If a tie occurs for the last eligible place in the ranking, the younger candidate prevails.

If one or more candidates renounce their place, the ranking will be scrolled down.

DEADLINE AND MODALITIES TO SUBMIT THE APPLICATION

The application must be signed and completed in a clear way, using the form available on the website; it must be submitted by April 10th 2021:

  • In person, at the University’s premises (hours: 9:00 – 1:00 pm, Monday to Friday)
  • Via registered mail, address: Scuola post-Laurea, UniCamillus University, Via di Sant’Alessandro, 8 – 00131 Roma
  • Via e-mail to: unicamillus@pec.it and postlaurea@unicamillus.org (please write in the Object the name of the Master the application is destined to)

 

The following documents must be sent along with the application form:

  • Curriculum vitae et studiorum, in European format, complete with date and signature
  • Photocopy of a valid ID
  • Copy of the certificate of the Degree achieved **
  • Certificate of any other possible degree that can be relevant for the selection procedure
  • Declaration of having seen the Informative on the Treatment of Personal Data according to art. 13-14 of the EU Regulation 2016/679 pertaining “the protection of individuals with respect to the treatment of personal data” (from now on, “GDPR”), provided by UniCamillus
  • Photocopy of the Fiscal code card and Healthcare card (for Italian and foreign citizens who have them)
  • For candidates with a degree equivalent/comparable to the ones required: declaration substituting the certificate, according to art. 46, letter: m) of the D.P.R. 28/12/2000, n. 445, which proves the achievement of the degree, in compliance with the current legislation
  • Declaration of Value released on site by the Italian consular authority of the country of the degree (with the transcript of records + copy of the final degree) or, Certification of Comparability CIMEA together with the certification of Verification by CIMEA (accessing the platform CIMEA) or, Diploma Supplement (if it is a European degree) issued by the University of origin and with a legalization by the Italian Embassy of the country of the degree. Candidates with some missing documents are admitted upon condition and are not allowed to complete the enrolment procedure until all the required certificates are presented.

The list of the eligible candidates, as well as the date and location of the selection procedure will be communicated on the UNICAMILLUS website.


DOCUMENTS TO BE DOWNLOADED


Call for Application

Enrolment

Privacy Policy

Foreign Studies Statement

   

PARTICIPATION FEES

The enrolment fee for the Master is Euro 2,500* to be paid in two instalments of equal amounts:

  • First instalment: Euro 1,500 to be paid by the enrolment deadline, which will be communicated by UniCamillus together with the communication of admission
  • Second instalment: Euro 1,000 to be paid by July 31st 2021

If the participant does not comply with the payment deadlines communicated by UniCamillus together with the eligibility for the Master course, he/she will lose his/her place and the ranking will be scrolled down until all the positions are called.

* The payment of the enrolment fees is not subject to V.A.T. according to the Art. 4 of the DPR 633/72, since it is included in the educational offer of the University. After the payment, a receipt will be issued as a proof of the payment.

CONTACTS

Scuola post-Laurea

UniCamillus – Saint Camillus International University of Health Sciences Via di Sant’Alessandro 8 – 00131 Roma

Website: www.unicamillus.org

Mail: postlaurea@unicamillus.org

Tel. 06 40 06 40

PEC: postlaurea.unicamillus@pec.it

 

Download the Master’s Brochure

(in Italian)

Master Genetica Oculare